| Product Name |
dihydroneopterin triphosphate aldolase |
| Example Structure |
 |
| Synonyms |
6-pyruvoyltetrahydropterin synthase, DHNA, dihydroneopterin aldolase, PTPS, PTPS-III |
| EC Number |
4.1.2.60 |
| CAS Registry Number |
|
| Comments |
The enzyme, which participates in a pathway for folate biosynthesis, is found in the Stramenopiles, a large group that includes oomycetes, various microalgae and brown algae, as well as in several bacterial phyla. It provides a bypass mechanism compensating for the lack of EC?4.1.2.25, dihydroneopterin aldolase. In the malaria parasite?Plasmodium falciparum?the enzyme is bifunctional and also catalyses the activity of EC?4.2.3.12, 6-pyruvoyltetrahydropterin synthase.?cf. EC?4.1.2.59, dihydroneopterin phosphate aldolase. |
| Cofactor |
|
| History |
|
| Reactions |
7,8-dihydroneopterin 3′-triphosphate = 6-(hydroxymethyl)-7,8- dihydropterin + glycolaldehyde triphosphate. |
