dihydropyrimidine dehydrogenase (NAD+) EC#: 1.3.1.1; ChemWhat Code: 1373936

Product Name dihydropyrimidine dehydrogenase (NAD+)
Example Structure Example Structure of dihydropyrimidine dehydrogenase (NAD+) EC#: 1.3.1.1
Synonyms dehydrogenase, dihydrouracil, dihydropyrimidine dehydrogenase, dihydrothymine dehydrogenase, dihydrouracil dehydrogenase (NAD+), DPD, pyrimidine deaminase/reductase, pyrimidine reductase, RibD, thymine reductase, uracil reductase
EC Number 1.3.1.1
CAS Registry Number 9026-89-5
Comments An iron-sulfur flavoenzyme. The enzyme was originally discovered in the uracil-fermenting bacterium, Clostridium uracilicum, which utilizes uracil and thymine as nitrogen and carbon sources for growth [1]. Since then the enzyme was found in additional organisms including Alcaligenes eutrophus [2], Pseudomonas strains [3,4] and Escherichia coli [5,6].
Cofactor flavoprotein;iron-sulfur
History
Reactions (1) 5,6-dihydrouracil + NAD(+) = uracil + Nadh. (2) 5,6-dihydrothymine + NAD(+) = thymine + Nadh.

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