| Product Name |
dipeptidase E |
| Example Structure |
 |
| Synonyms |
alpha-aspartyl dipeptidase, Asp-specific dipeptidase, aspartyl dipeptidase, dipeptidase E, PepE gene product, Salmonella typhimurium, peptidase E |
| EC Number |
3.4.13.21 |
| CAS Registry Number |
|
| Comments |
A free carboxy group is not absolutely required in the substrate since Asp-Phe-NH2?and Asp-Phe-OMe are hydrolysed somewhat more slowly than dipeptides with free C-termini. No peptide larger than a C-blocked dipeptide is known to be a substrate. Asp-NH-Np is hydrolysed and is a convenient substrate for routine assay. The enzyme is most active near pH 7.0, and is not inhibited by di-isopropylfluorophosphate or phenylmethanesulfonyl fluoride. Belongs in peptidase family?S51. |
| Cofactor |
|
| History |
|
| Reactions |
Dipeptidase E catalyzes the hydrolysis of dipeptides Asp-|-Xaa. It does not act on peptides with N-terminal Glu, Asn or Gln, nor does it cleave isoaspartyl peptides. |
