| Product Name |
diphthine-ammonia ligase |
| Example Structure |
 |
| Synonyms |
Diphthamide synthase, diphthamide synthetase, DPH6, Synthetase, diphthamide, YLR143w |
| EC Number |
6.3.1.14 |
| CAS Registry Number |
114514-33-9 |
| Comments |
This amidase catalyses the last step in the conversion of an?L-histidine residue in the translation elongation factor translation elongation factor 2 to diphthamide. This factor is found in all archaebacteria and eukaryotes, but not in eubacteria, and is the target of bacterial toxins such as the diphtheria toxin and the?Pseudomonas?exotoxin A (see EC?2.4.2.36, NAD+¡ªdiphthamide ADP-ribosyltransferase). The substrate of the enzyme, diphthine, is produced by EC?2.1.1.98, diphthine synthase. |
| Cofactor |
|
| History |
|
| Reactions |
Atp + diphthine-[translation elongation factor 2] + NH(3) = amp + diphosphate + diphthamide-[translation elongation factor 2]. |
