ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] EC#: 2.5.1.87; ChemWhat Code: 1378019

Product Name ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific]
Example Structure Example Structure of ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] EC#: 2.5.1.87
Synonyms AcpT, anther-66, cis-prenyltransferase, cis-PTase, Dedol-PP synthase, DedolPP synthase, dehydrodolichyl diphosphate synthase, dehydrodolichyl diphosphate synthase 1, DHDDS, NgBR, Nogo-B receptor, RER2, Rer2p, Rer2p Z-prenyltransferase, SlCPT3, SRT1, Srt1p, Srt2p Z-prenyltransferase, Tk-IdsB
EC Number 2.5.1.87
CAS Registry Number
Comments The enzyme is involved in biosynthesis of dolichol (a long-chain polyprenol) with a saturated ¦Á-isoprene unit, which serves as a glycosyl carrier in protein glycosylation [1]. The yeast Saccharomyces cerevisiae has two different enzymes that catalyse this reaction. Rer2p synthesizes a well-defined family of polyprenols of 13-18 isoprene residues with dominating C80 (16 isoprene residues) extending to C120, while Srt1p synthesizes mainly polyprenol with 22 isoprene subunits. Largest Srt1p products reach C290 [2]. The enzyme from Arabidopsis thaliana catalyses the formation of polyprenyl diphosphates with predominant carbon number C120 [4].
Cofactor
History
Reactions (2E,6E)-farnesyl diphosphate + n isopentenyl diphosphate = n diphosphate + ditrans,polycis-polyprenyl diphosphate (n = 10-55).

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