DNA-3′-diphospho-5′-guanosine diphosphatase EC#: 3.1.12.2; ChemWhat Code: 1379711
| Product Name | DNA-3′-diphospho-5′-guanosine diphosphatase |
| Example Structure |  |
| Synonyms | aprataxin, APTX, DNA-3’pp5’G guanylate hydrolase, HNT3 |
| EC Number | 3.1.12.2 |
| CAS Registry Number | |
| Comments | Aprataxin is a DNA-binding protein that catalyses (among other activities) the 3′ decapping of DNA-ppG (formed by EC?6.5.1.8, 3′-phosphate/5′-hydroxy nucleic acid ligase) [1]. The enzyme binds the guanylate group to a histidine residue at its active site, forming a covalent enzyme-nucleotide phosphate intermediate, followed by the hydrolysis of the guanylate from the nucleic acid and its eventual release. The enzyme also possesses the activity of EC?3.1.11.7, DNA-(5′-diphosphoadenosine) diphosphatase, and EC?3.1.11.8, 5′-diphosphoguanosinylyl-(3′-5′)-[DNA] diphosphatase. |
| Cofactor | |
| History | |
| Reactions | (DNA)-3′-diphospho-5′-guanosine + H(2)O = (DNA)-3′-phosphate + Gmp. |
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