DNA N6-methyladenine demethylase EC#: 1.14.11.51; ChemWhat Code: 1375144
| Product Name | DNA N6-methyladenine demethylase |
| Example Structure |  |
| Synonyms | 6mA DNA demethylase, ALKBH1, DMAD, DNA 6mA demethylase, NMAD-1 |
| EC Number | 1.14.11.51 |
| CAS Registry Number | |
| Comments | Contains iron(II). Catalyses oxidative demethylation of DNA N6-methyladenine, a prevalent modification in LINE-1 transposons, which are specifically enriched on the human X chromosome. |
| Cofactor | Fe3+ |
| History | |
| Reactions | N(6)-methyladenine in Dna + 2-oxoglutarate + O(2) = adenine in dna + formaldehyde + succinate + CO(2). |
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