DNA oxidative demethylase EC#: 1.14.11.33; ChemWhat Code: 1375118
| Product Name | DNA oxidative demethylase |
| Example Structure |  |
| Synonyms | 1-methyladenine-DNA dioxygenase, ABH1, ABH2, ABH3, AlkB, AlkB homolog 1, ALKBH2, ALKBH3, ALKBH8, alkylated DNA repair protein, alpha-ketoglutarate-dependent dioxygenase ABH1, FTO |
| EC Number | 1.14.11.33 |
| CAS Registry Number | |
| Comments | Contains iron; activity is slightly stimulated by ascorbate. Catalyses oxidative demethylation of the DNA base lesions N1-methyladenine, N3-methylcytosine, N1-methylguanine, and N3-methylthymine. It works better on single-stranded DNA (ssDNA) and is capable of repairing damaged bases in RNA. |
| Cofactor | Fe cation |
| History | |
| Reactions | DNA-base-CH(3) + 2-oxoglutarate + O(2) = DNA-base + formaldehyde + succinate + CO(2). |
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