The enzyme, characterized from the methanogenic archaeon Methanococcus voltae, participates in the N-glycosylation of proteins. Dolichol used by archaea is different from that used by eukaryotes; it is much shorter (C55-C60), it is ¦Á,¦Ø-saturated and it may have additional unsaturated positions in the chain.
Cofactor
History
Reactions
UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate + an archaeal dolichyl N-acetyl-alpha-D-glucosaminyl phosphate = Udp + an archaeal dolichyl 3-O-(2,3-diacetamido-2,3-dideoxy-beta-D-glucuronsyl)-N-acetyl- alpha-D-glucosaminyl phosphate.
