double-stranded uracil-DNA glycosylase EC#: 3.2.2.28; ChemWhat Code: 1380183
| Product Name | double-stranded uracil-DNA glycosylase |
| Example Structure |  |
| Synonyms | double stranded DNA specific UDG, double-strand uracil-DNA glycosylase, double-stranded uracil-DNA glycosylase, dsDNA specific UDG, dsUDG, Dug, family 5 UDGb, family 5 uracil DNA glycosylase, G:T/U mismatch-specific DNA glycosylase, More, MUG, UDG, UdgB, uracil DNA glycosylase |
| EC Number | 3.2.2.28 |
| CAS Registry Number | |
| Comments | No activity on DNA containing a T/G mispair or single-stranded DNA containing either a site-specific uracil or 3,N4-ethenocytosine residue [2], significant role for double-stranded uracil-DNA glycosylase in mutation avoidance in non-dividing?Escherichia coli?[3]. Uracil-DNA glycosylases are widespread enzymes that are found in all living organisms. Uracil-DNA glycosylase (EC?3.2.2.27) and double-stranded uracil-DNA glycosylase (EC?3.2.2.28) form a central part of the DNA-repair machinery since they initiate the DNA base-excision repair pathway by hydrolysing the?N-glycosidic bond between uracil and the deoxyribose sugar thereby catalysing the removal of mis-incorporated uracil from DNA. |
| Cofactor | |
| History | |
| Reactions | Specifically hydrolyzes mismatched double-stranded Dna and polynucleotides, releasing free uracil. |
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