| Product Name |
dTDP-4-amino-4,6-dideoxy-D-glucose ammonia-lyase |
| Example Structure |
 |
| Synonyms |
DesII |
| EC Number |
4.3.1.30 |
| CAS Registry Number |
|
| Comments |
The enzyme, which is a member of the ‘AdoMet radical’ (radical SAM) family, is involved in biosynthesis of TDP-¦Á-D-desosamine. The reaction starts by the transfer of an electron from the reduced form of the enzyme’s [4Fe-4S] cluster to?S-adenosyl-L-methionine, spliting it into methionine and the radical 5-deoxyadenosin-5′-yl, which attacks the sugar substrate. |
| Cofactor |
iron-sulfur |
| History |
|
| Reactions |
dTDP-4-amino-4,6-dideoxy-alpha-D-glucopyranose + S-adenosyl-L-methionine + reduced acceptor = dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucopyranose + NH(3) + L-methionine + 5′-deoxyadenosine + acceptor. |
