endo-alpha-N-acetylgalactosaminidase EC#: 3.2.1.97; ChemWhat Code: 1379973
| Product Name | endo-alpha-N-acetylgalactosaminidase |
| Example Structure |  |
| Synonyms | acetylgalactosaminidase, endo-alpha, D-galactosyl-N-acetyl-alpha-D-galactosamine D-galactosyl-N-acetylgalactosaminohydrolase, endo GalNAc-ase S, endo-alpha-acetylgalactosaminidase, endo-alpha-GalNAc-ase, endo-alpha-N-acetylgalactosaminidase, endo-alpha-N-acetylgalactosaminidase S, endo-beta-N-acetylgalactosaminidase, endo-EF, endo-GalNAc-ase S, endoEF, EngBF, EngCP, More, NagBb, SpGH101 |
| EC Number | 3.2.1.97 |
| CAS Registry Number | 59793-96-3 |
| Comments | The enzyme catalyses the liberation of Gal-(1¡ú3)-¦Â-GalNAc ¦Á-linked to serine or threonine residues of mucin-type glycoproteins. EngBF from?Bifidobacterium longum?specifically acts on core 1-type?O-glycan to release the disaccharide Gal-(1¡ú3)-¦Â-GalNAc. The enzymes from?Clostridium perfringens,?Enterococcus faecalis,?Propionibacterium acnes?and?Alcaligenes faecalis?show broader specificity (e.g. release of the core 2 trisaccharide Gal-(1¡ú3)-¦Â-(GlcNAc-(1¡ú6)-¦Â)-GalNAc or the core 3 disaccharide GlcNAc-(1¡ú3)-¦Â-GalNAc) [1,2]. The enzyme may play an important role in the degradation and utilization of mucins having core 1?O-glycan. |
| Cofactor | |
| History | |
| Reactions | 3-O-beta-D-galactosyl-N-acetyl-alpha-D-galactosaminyl-L-serine-[protein] + H(2)O = 3-O-beta-D-galactosyl-N-acetyl-alpha-D-galactosamine + L-serine-[protein]. |
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