| Product Name |
enterobactin synthase |
| Example Structure |
 |
| Synonyms |
2,3-Dihydroxy-N-benzoyl-L-serine synthetase, 2,3-Dihydroxybenzoylserine synthetase, DBS synthetase, DHBS synthase, EntE, N-(2,3-Dihydroxybenzoyl)-serine synthetase, Synthetase, 2,3-dihydroxybenzoylserine |
| EC Number |
6.3.2.14 |
| CAS Registry Number |
37318-63-1 |
| Comments |
This enzyme complex catalyses the conversion of three molecules each of 2,3-dihydroxybenzoate and?L-serine to form the siderophore enterobactin. In?Escherichia coli?the complex is formed by EntB (an aryl carrier protein that has to be activated by 4′-phosphopantetheine), EntD (a phosphopantetheinyl transferase that activates EntB), EntE (catalyses the ATP-dependent condensation of 2,3-dihydroxybenzoate and holo-EntB to form the covalently arylated form of EntB), and EntF (a four domain protein that catalyses the activation of?L-serine by ATP, the condensation of the activated?L-serine with the activated 2,3-dihydroxybenzoate, and the trimerization of three such moieties to a single enterobactin molecule). |
| Cofactor |
|
| History |
|
| Reactions |
6 Atp + 3 2,3-dihydroxybenzoate + 3 L-serine = enterobactin + 6 amp + 6 diphosphate. |
