epi-isozizaene 5-monooxygenase EC#: 1.14.13.106; ChemWhat Code: 1375333
| Product Name | epi-isozizaene 5-monooxygenase |
| Example Structure |  |
| Synonyms | albaflavenone synthase, CYP170A1 |
| EC Number | 1.14.13.106 |
| CAS Registry Number | 1207718-51-1 |
| Comments | This cytochrome-P450 enzyme, from the soil-dwelling bacterium Streptomyces coelicolor A3(2), catalyses two sequential allylic oxidation reactions. The substrate epi-isozizaene, which is formed by the action of EC 4.2.3.37, epi-isozizaene synthase, is first oxidized to yield the epimeric intermediates (5R)-albaflavenol and (5S)-albaflavenol, which can be further oxidized to yield the sesquiterpenoid antibiotic albaflavenone. |
| Cofactor | |
| History | |
| Reactions | (+)-epi-isozizaene + 2 Nadph + 2 O(2) = albaflavenone + 2 NADP(+) + 3 H(2)O. |
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