Fas-activated serine/threonine kinase, Fas-activated serine/threonine phosphoprotein, FAST K, FASTK, FASTKD2
EC Number
2.7.11.8
CAS Registry Number
Comments
This enzyme is activated during Fas-mediated apoptosis. Following Fas ligation, the enzyme, which is constitutively phosphorylated, is dephosphorylated, and it is the dephosphorylated form that causes phosphorylation of TIA-1, a nuclear RNA-binding protein. Phosphorylation of TIA-1 precedes the onset of DNA fragmentation. Formerly EC?2.7.1.37.
