folate gamma-glutamyl hydrolase EC#: 3.4.19.9; ChemWhat Code: 1380430

Product Name folate gamma-glutamyl hydrolase
Example Structure Example Structure of folate gamma-glutamyl hydrolase EC#: 3.4.19.9
Synonyms At1g78680, AtGGH1, AtGGH2, carboxypeptidase G, conjugase, EC 3.4.12.10, EC 3.4.22.12, FGPH, folate conjugase, folate hydrolase, folic acid conjugase, folylpolyglutamate hydrolase, gamma-GH, gamma-Glu-X carboxypeptidase, gamma-glutamyl hydrolase, gamma-polyglutamic acid hydrolase, gammaGH, GGH, GGH2, hydrolase, gamma-glutamyl, LeGGH1, LeGGH2, LeGGH3, low gamma-glutamyl hydrolase, lysosomal gamma-glutamyl carboxypeptidase, PghP, poly(gamma-glutamic acid) endohydrolase, poly(glutamic acid) hydrolase II, polyglutamate hydrolase, pteroyl-poly-gamma-glutamate hydrolase, pteroylpoly-gamma-glutamyl hydrolase, zgammaGH
EC Number 3.4.19.9
CAS Registry Number 9074-87-7
Comments The enzyme, which occurs only in animals and plants, can be either endo- and/or exopeptidase. It acts on tetrahydropteroyl polyglutamates and their modified forms, as well as the polyglutamates of the folate breakdown product?N-(4-aminobenzoyl)-L-glutamate (pABA-Glu). The initial cleavage may release either monoglutamate or poly-¦Ã-glutamate of two or more residues, depending on the specific enzyme. For example, GGH1 from the plant?Arabidopsis thaliana?cleaves pentaglutamates, mainly to di- and triglutamates, whereas GGH2 from the same organism yields mainly monoglutamates. The enzyme is lysosomal (and secreted) in animals and vacuolar in plants. Belongs to peptidase family?C26. Formerly EC?3.4.12.10?and EC?3.4.22.12.
Cofactor
History
Reactions Hydrolysis of a gamma-glutamyl bond.

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