| Product Name |
formate-phosphoribosylaminoimidazolecarboxamide ligase |
| Example Structure |
 |
| Synonyms |
5-formaminoimidazole-4-carboxamide ribonucleotide synthetase, 5-formaminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5′-monophosphate synthetase, PurP |
| EC Number |
6.3.4.23 |
| CAS Registry Number |
|
| Comments |
This archaeal enzyme, characterized from the methanogen?Methanocaldococcus jannaschii, catalyses a step in the synthesis of purine nucleotides. It differs from the orthologous bacterial/eukaryotic enzymes, which utilize 10-formyltetrahydrofolate rather than formate and ATP.?cf. EC?2.1.2.3, phosphoribosylaminoimidazolecarboxamide formyltransferase. |
| Cofactor |
|
| History |
|
| Reactions |
Atp + formate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = Adp + phosphate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4- carboxamide. |
