gamma-glutamyltransferase EC#: 2.3.2.2; ChemWhat Code: 1377140

Product Name gamma-glutamyltransferase
Example Structure Example Structure of gamma-glutamyltransferase EC#: 2.3.2.2
Synonyms (5-L-glutamyl) peptide: amino-acid 5-glutamyl transferase, alpha-glutamyl transpeptidase, At1g69820, At4g29210, At4g39640, At4g39650, gamma glutamyl transferase, gamma-glutamyl peptidyltransferase, gamma-glutamyl transferase, gamma-glutamyl transferase 5, gamma-glutamyl transferases, gamma-glutamyl transpeptidase, gamma-glutamyl transpeptidase 4, gamma-glutamyl transpeptidase-1, gamma-glutamyltranspeptidase, gamma-GPT, gamma-GT, gamma-GTase, gamma-GTP, gammaGT, GGT, GGT A, GGT I, GGT-1, GGT1, GGT2, GGT3, GGT4, GGT5, GGTII protein, GGTLA1, glutamyl transpeptidase, glutamyltransferase, gamma-, L-gamma-glutamyl transpeptidase, L-gamma-glutamyltransferase, L-glutamyltransferase
EC Number 2.3.2.2
CAS Registry Number 9046-27-9
Comments The mammlian enzyme is part of the cell antioxidant defense mechanism. It initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracelular GSH levels. The protein also has EC 3.4.19.13 (glutathione hydrolase) activity [3-4]. The enzyme consists of two chains that are created by the proteolytic cleavage of a single precursor polypeptide. The N-terminal L-threonine of the C-terminal subunit functions as the active site for both the cleavage and the hydrolysis reactions [3-4].
Cofactor
History
Reactions A (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid.

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