Cyc2, germacradienol synthase, germacradienol/geosmin synthase, germacradienol/germacrene D synthase, germacrene D synthase, GS, sesquiterpene synthase, spterp13, terpene cyclase
EC Number
4.2.3.22
CAS Registry Number
Comments
Requires Mg2+?for activity. H-1si?of farnesyl diphosphate is lost in the formation of (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol. Formation of (?)-germacrene D involves a stereospecific 1,3-hydride shift of H-1si?of farnesyl diphosphate. Both products are formed from a common intermediate [2]. Other enzymes produce germacrene D as the sole product using a different mechanism. The enzyme mediates a key step in the biosynthesis of geosmin (see EC?4.1.99.16?geosmin synthase), a widely occurring metabolite of many streptomycetes, bacteria and fungi [2]. Also catalyses the reaction of EC?4.2.3.75, (?)-germacrene D synthase.
