gingipain R EC#: 3.4.22.37; ChemWhat Code: 1380745

Product Name gingipain R
Example Structure Example Structure of gingipain R EC#: 3.4.22.37
Synonyms Arg gingipain, Arg-gingipain, Arg-gingipain A, Arg-gingipain B, Arg-gingipains B, Arg-gingivain-55 proteinase, Arg-gingivain-70 proteinase, Arg-gingivain-75 proteinase, Arg-gingivain-specific proteinase, Arg-ginigipain A, Arg-ginigipain B, Arg-specific cysteine protease, Arg-specific cysteine proteinase, Arg-specific cysteine proteinase gingipain, Arg-specific gingipain, Arg-specific gingipain protease, Arg-X proteinase, Arg-X-specific Arg gingipain, Argingipain, arginine gingipain, arginine-gingipain, Arginine-specific cysteine protease, arginine-specific cysteine proteinase, Arginine-specific gingipain, arginine-specific gingipain 2, arginine-specific gingipain B, arginine-specific gingipain proteinase, Arginine-specific gingivain, arginine-X specific cysteine proteinase, gingipain, gingipain B, gingipain R, gingipain R2, Gingipain-1, gingipain-R, Gingivain, arginine-specific, high molecular mass arginine-specific gingipain A, high molecular weight gingipain A, high-molecular-mass arginine-specific gingipain, HRgpA, HrgpB, low molecular weight gingipain B, More, mt-RgpA, mt-RgpB, RgB, RGP, Rgp proteinase, RGP-1, RGP-2, RgpA, RgpA proteinase, RgpA(cat), RgpB
EC Number 3.4.22.37
CAS Registry Number 159745-71-8
Comments A secreted endopeptidase from the bacterium?Porphyromonas gingivalis. Strongly activated by glycine [1], and stabilized by Ca2+. Precursor molecule contains a hemagglutinin domain [2, 3]. Misleadingly described in some literature as “trypsin-like”, being a cysteine peptidase, type example of family?C25.
Cofactor
History
Reactions Hydrolysis of proteins and small molecule substrates, with a preference for Arg in P1.

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