gluconate/galactonate dehydratase EC#: 4.2.1.140; ChemWhat Code: 1382448

Product Name gluconate/galactonate dehydratase
Example Structure Example Structure of gluconate/galactonate dehydratase EC#: 4.2.1.140
Synonyms D-gluconate dehydratase, GNAD, Pto0485, Sso3198
EC Number 4.2.1.140
CAS Registry Number
Comments The enzyme is involved in glucose and galactose catabolism via the nonphosphorylative variant of the Entner-Doudoroff pathway in?Picrophilus torridus?[3] and via the branched variant of the Entner-Doudoroff pathway in?Sulfolobus solfataricus?[1,2].?In vitro?it utilizes?D-gluconate with 6-10 fold higher catalytic efficiency than?D-galactonate [1,3]. It requires Mg2+?for activity [1,2].?cf. EC?4.2.1.6, galactonate dehydratase, and EC?4.2.1.39, gluconate dehydratase.
Cofactor Mg2+
History
Reactions (1) D-gluconate = 2-dehydro-3-deoxy-D-gluconate + H(2)O. (2) D-galactonate = 2-dehydro-3-deoxy-D-galactonate + H(2)O.

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