gluconate/galactonate dehydratase EC#: 4.2.1.140; ChemWhat Code: 1382448
| Product Name | gluconate/galactonate dehydratase |
| Example Structure |  |
| Synonyms | D-gluconate dehydratase, GNAD, Pto0485, Sso3198 |
| EC Number | 4.2.1.140 |
| CAS Registry Number | |
| Comments | The enzyme is involved in glucose and galactose catabolism via the nonphosphorylative variant of the Entner-Doudoroff pathway in?Picrophilus torridus?[3] and via the branched variant of the Entner-Doudoroff pathway in?Sulfolobus solfataricus?[1,2].?In vitro?it utilizes?D-gluconate with 6-10 fold higher catalytic efficiency than?D-galactonate [1,3]. It requires Mg2+?for activity [1,2].?cf. EC?4.2.1.6, galactonate dehydratase, and EC?4.2.1.39, gluconate dehydratase. |
| Cofactor | Mg2+ |
| History | |
| Reactions | (1) D-gluconate = 2-dehydro-3-deoxy-D-gluconate + H(2)O. (2) D-galactonate = 2-dehydro-3-deoxy-D-galactonate + H(2)O. |
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