glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase EC#: 2.4.1.175; ChemWhat Code: 1377469
| Product Name | glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase |
| Example Structure |  |
| Synonyms | acetylgalactosaminyltransferase, uridine diphosphoacetylgalactosamine-chondroitin, II, ChGn-1, ChGn-2, chondroitin galactosaminyltransferase, chondroitin N-acetylgalactosaminyltransferase-1, chondroitin N-acetylgalactosaminyltransferase-2, chondroitin polymerase, chondroitin sulfate beta-1,4-N-acetylgalactosaminyltransferase-1, chondroitin sulfate glucuronyltransferase, chondroitin sulfate glycosyltransferase, chondroitin sulfate synthase 1, chondroitin sulfate synthase-1, chondroitin sulfate synthase-2, chondroitin sulfate synthase-2/chondroitin polymerizing factor, chondroitin sulfate synthase-3, chondroitin synthase, chondroitin synthase 1, chondroitin synthase-1, chondroitin synthase-2, chondroitin synthase-3, ChSy, ChSy-1, ChSy-2, ChSy-3, CHSY1, CS glycosyltransferase, CS synthase-1, CSGalNAcT-2, CSGlcA-T, CSS2, CSS3, glucuronyl-N-acetylgalactosaminylproteoglycan beta1,4-N-acetylgalactosaminyltransferase, K4CP, More, N-acetylgalactosaminyltransferase II, UDP-N-acetyl-D-galactosamine:D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase, uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferasec II |
| EC Number | 2.4.1.175 |
| CAS Registry Number | 96189-40-1 |
| Comments | Involved in the biosynthesis of chondroitin sulfate. The human form of this enzyme is a bifunctional glycosyltransferase, which also has the 3-¦Â-glucuronosyltransferase (EC 2.4.1.226) activity required for the synthesis of the chondroitin sulfate disaccharide repeats. Similar chondroitin synthase ‘co-polymerases’ can be found in Pasteurella multocida and Escherichia coli. |
| Cofactor | |
| History | |
| Reactions | UDP-N-acetyl-alpha-D-galactosamine + beta-D-glucuronosyl-(1->3)-N-acetyl- beta-D-galactosaminyl-proteoglycan = Udp + N-acetyl-beta-D- galactosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D- galactosaminyl-proteoglycan. |
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