glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase EC#: 2.4.1.174; ChemWhat Code: 1377468
| Product Name | glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase |
| Example Structure |  |
| Synonyms | acetylgalactosaminyltransferase, uridine diphosphoacetylgalactosamine-chondroitin, I, ChGn-1, ChGn-2, chondroitin beta1,4-N-acetylgalactosaminyltransferase-1, chondroitin galactosaminyltransferase, chondroitin N-acetylgalactosaminyltransferase-1, chondroitin N-acetylgalactosaminyltransferase-2, chondroitin sulfate beta-1,4-N-acetylgalactosaminyltransferase-1 ChGn-1, chondroitin sulfate N-acetylgalactosaminyltransferase 1, chondroitin sulfate N-acetylgalactosaminyltransferase-1, chondroitin sulfate N-acetylgalactosaminyltransferase-2, chondroitin sulfate synthase 1, chondroitin sulfate synthase-1, chondroitin sulphate N-acetylgalactosaminyl-transferase-1, chondroitin sulphate N-acetylgalactosaminyltransferase 1, CHSY1, CS N-acetylgalactosaminyltransferase 1, CS N-acetylgalactosaminyltransferase-1, CSGalNAcT-1, CSGalNAcT1, CSGALNACT2, CSS1, GalNAcT-I, GalNAcT-II, glucuronylgalactosylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase, More, N-acetylgalactosamineT-II, N-acetylgalactosaminyltransferase I, uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferase I |
| EC Number | 2.4.1.174 |
| CAS Registry Number | 96189-39-8 |
| Comments | Requires Mn2+. Involved in the biosynthesis of chondroitin sulfate. Key enzyme activity for the initiation of chondroitin and dermatan sulfates, transferring GalNAc to the GlcA-Gal-Gal-Xyl-Ser core. |
| Cofactor | |
| History | |
| Reactions | UDP-N-acetyl-D-galactosamine + [protein]-3-O-(beta-D-GlcA-(1->3)-beta-D- Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine = Udp + [protein]-3- O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal- (1->4)-beta-D-Xyl)-L-serine. |
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