A zinc enzyme produced by pseudomonads,?Flavobacterium?sp. and?Acinetobacter?sp. Its ability to hydrolyse pteroyl-L-glutamate (folic acid) has led to its use as a folate-depleting, antitumour agent. Type example of peptidase family?M20.
Cofactor
Zn2+
History
Reactions
Release of C-terminal glutamate residues from a wide range of N-acylating moieties, including peptidyl, aminoacyl, benzoyl, benzyloxycarbonyl, folyl and pteroyl groups.
