| Product Name |
glycine N-methyltransferase |
| Example Structure |
 |
| Synonyms |
4S polycyclic aromatic hydrocarbon binding protein, glycine methyltransferase, glycine N-methyltransferase, glycine-N methyltransferase, GNMT, Gnmt gene product, methyltransferase, glycine, S-adenosyl-L-methionine:glycine methyltransferase |
| EC Number |
2.1.1.20 |
| CAS Registry Number |
37228-72-1 |
| Comments |
This enzyme is thought to play an important role in the regulation of methyl group metabolism in the liver and pancreas by regulating the ratio between S-adenosyl-L-methionine and S-adenosyl-L-homocysteine. It is inhibited by 5-methyltetrahydrofolate pentaglutamate [4]. Sarcosine, which has no physiological role, is converted back into glycine by the action of EC 1.5.8.3, sarcosine dehydrogenase. |
| Cofactor |
|
| History |
|
| Reactions |
S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine. |
