glycosylphosphatidylinositol phospholipase D EC#: 3.1.4.50; ChemWhat Code: 1379627
Product Name | glycosylphosphatidylinositol phospholipase D |
Example Structure | |
Synonyms | glycoprotein phospholipase D, glycosylphophatidylinositol-specific phospholipase D, glycosylphosphatidylinositol-phospholipase D, glycosylphosphatidylinositol-specific phospholipase D, GPI-PDL, GPI-PLD, GPI-specific phospholipase D, Gpld1, phosphatidylinositol phospholipase D, phosphatidylinositol-specific phospholipase D, phospholipase D, phospholipase D, phosphatidylinositol, PI-G PLD |
EC Number | 3.1.4.50 |
CAS Registry Number | 113756-14-2 |
Comments | This enzyme is also active when O-4 of the glucosamine is substituted by carrying the oligosaccharide that can link a protein to the structure. It therefore cleaves proteins from the lipid part of the glycosylphosphatidylinositol (GPI) anchors, but does so by hydrolysis, whereas glycosylphosphatidylinositol diacylglycerol-lyase (EC?4.6.1.14) does so by elimination. It acts on plasma membranes only after solubilization of the substrate with detergents or solvents, but it may act on intracellular membranes. |
Cofactor | |
History | |
Reactions | 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(2)O = 6-(alpha-D-glucosaminyl)-1D-myo-inositol + phosphatidate. |
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