glycosylphosphatidylinositol phospholipase D EC#: 3.1.4.50; ChemWhat Code: 1379627

Product Name glycosylphosphatidylinositol phospholipase D
Example Structure Example Structure of glycosylphosphatidylinositol phospholipase D EC#: 3.1.4.50
Synonyms glycoprotein phospholipase D, glycosylphophatidylinositol-specific phospholipase D, glycosylphosphatidylinositol-phospholipase D, glycosylphosphatidylinositol-specific phospholipase D, GPI-PDL, GPI-PLD, GPI-specific phospholipase D, Gpld1, phosphatidylinositol phospholipase D, phosphatidylinositol-specific phospholipase D, phospholipase D, phospholipase D, phosphatidylinositol, PI-G PLD
EC Number 3.1.4.50
CAS Registry Number 113756-14-2
Comments This enzyme is also active when O-4 of the glucosamine is substituted by carrying the oligosaccharide that can link a protein to the structure. It therefore cleaves proteins from the lipid part of the glycosylphosphatidylinositol (GPI) anchors, but does so by hydrolysis, whereas glycosylphosphatidylinositol diacylglycerol-lyase (EC?4.6.1.14) does so by elimination. It acts on plasma membranes only after solubilization of the substrate with detergents or solvents, but it may act on intracellular membranes.
Cofactor
History
Reactions 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(2)O = 6-(alpha-D-glucosaminyl)-1D-myo-inositol + phosphatidate.

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