GTP cyclohydrolase IIa EC#: 3.5.4.29; ChemWhat Code: 1381471

Product Name GTP cyclohydrolase IIa
Example Structure Example Structure of GTP cyclohydrolase IIa EC#: 3.5.4.29
Synonyms GCH III, GTP cyclohydrolase III, MJ0145
EC Number 3.5.4.29
CAS Registry Number
Comments Requires Mg2+. This enzyme catalyses the hydrolysis of the imidazole ring of guanosine 5′-triphosphate,?N7-methylguanosine 5′-triphosphate or inosine 5′-triphosphate. Xanthosine 5′-triphosphate and ATP are not substrates. It also catalyses the hydrolysis of diphosphate to form two equivalents of phosphate. Unlike GTP cyclohydrolase II (EC?3.5.4.25), this enzyme does not release formate, but does hydrolyze the diphosphate from GTP to phosphate.
Cofactor Mg2+
History
Reactions Gtp + 3 H(2)O = 2-amino-5-formylamino-6-(5-phospho-D- ribosylamino)pyrimidin-4(3H)-one + 2 phosphate.

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