H2:CoB-CoM heterodisulfide,ferredoxin reductase EC#: 1.8.98.5; ChemWhat Code: 1374759

Product Name H2:CoB-CoM heterodisulfide,ferredoxin reductase
Example Structure Example Structure of H2:CoB-CoM heterodisulfide,ferredoxin reductase EC#: 1.8.98.5
Synonyms F420-non-reducing hydrogenase, H2: heterodisulfide oxidoreductase complex, HdrA, HdrABC, HdrB, HdrC, Mvh, MvhA, MvhADG, MvhADG/HdrABC, MvhD, MvhG
EC Number 1.8.98.5
CAS Registry Number
Comments This enzyme complex is found in H2-oxidizing CO2-reducing methanogenic archaea such as Methanothermobacter thermautotrophicus. It consists of a cytoplasmic complex of HdrABC reductase and MvhAGD hydrogenase. Electron pairs donated by the hydrogenase are transferred via its ¦¤ subunit to the HdrA subunit of the reductase, where they are bifurcated, reducing both ferredoxin and CoB-CoM heterodisulfide. The reductase can also form a similar complex with formate dehydrogenase, see EC 1.8.98.6, formate:CoB-CoM heterodisulfide,ferredoxin reductase. cf. EC 1.8.7.3, ferredoxin:CoB-CoM heterodisulfide reductase, EC 1.8.98.4, coenzyme F420:CoB-CoM heterodisulfide,ferredoxin reductase, and EC 1.8.98.1, dihydromethanophenazine:CoB-CoM heterodisulfide reductase.
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