helper-component proteinase EC#: 3.4.22.45; ChemWhat Code: 1380761
| Product Name | helper-component proteinase |
| Example Structure |  |
| Synonyms | HC-Pro, HC-Pro protein, HC-Pro proteinase, HcPro, helper component protease, helper component proteinase, helper component-protease, helper component-proteinase, helper-component proteinase, More, potyvirus helper component proteinase, strong silencing suppressor P1 |
| EC Number | 3.4.22.45 |
| CAS Registry Number | |
| Comments | Known from many potyviruses. The helper component-proteinase of the tobacco etch virus is a multifunctional protein with several known activities: the N-terminal region is required for aphid transmission and efficient genome amplification, the central region is required for long-distance movement in plants, and the C-terminal domain has cysteine endopeptidase activity. Type example of peptidase family?C6. |
| Cofactor | |
| History | |
| Reactions | Hydrolyzes a Gly-|-Gly bond at its own C-terminus, commonly in the sequence -Tyr-Xaa-Val-Gly-|-Gly, in the processing of the potyviral polyprotein. |
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