hepacivirin EC#: 3.4.21.98; ChemWhat Code: 1380633
| Product Name | hepacivirin |
| Example Structure |  |
| Synonyms | Cpro-2, Cpro-2 proteinase, Den2 protease, HCV NS3, HCV NS3 protease, HCV NS3/4A, Hepacivirin, hepatitis C virus NS3 serine protease, non-structural 3 protein, nonstructural 3 protease, nonstructural protein 3, NS2/3 protease, NS2B-NS3 proteinase, NS2B/NS3 protease, NS3, NS3 protease, NS3 proteinase, NS3 serine protease, NS3 serine proteinase, NS3-4A, NS3-4A protease, NS3-4A serine protease, NS3-4A serine protease complex, NS3-4A serine proteinase, NS3-NS4A protease, NS3-protease, NS3-SP, NS3/4a, NS3/4A protease, NS3/4A serine protease, NS5A-5B protease, P70, polyprotein-processing proteinase NS3, proteinase NS3, proteinase, polyprotein-processing, NS3, sc-protease, serine protease NS3, serine proteinase NS3 |
| EC Number | 3.4.21.98 |
| CAS Registry Number | 149885-80-3 |
| Comments | Encoded by the genome of the viruses of the hepatitis C group, and contributes to the maturation of the precursor polyproteins. The enzyme is greatly activated by binding of the 54-residue NS4A ‘cofactor’ protein also derived from the viral polyprotein. Type example of peptidase family?S29. The crystallographic structure shows a chymotrypsin-like fold. |
| Cofactor | |
| History | |
| Reactions | Hydrolysis of four peptide bonds in the viral precursor polyprotein, commonly with Asp or Glu in the P6 position, Cys or Thr in P1 and Ser or Ala in P1′. |
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