[heparan sulfate]-glucosamine 3-sulfotransferase 2 EC#: 2.8.2.29; ChemWhat Code: 1379114

Product Name [heparan sulfate]-glucosamine 3-sulfotransferase 2
Example Structure Example Structure of [heparan sulfate]-glucosamine 3-sulfotransferase 2 EC#: 2.8.2.29
Synonyms 3-O-sulfotransferase-2, 3-OST-2, 3-OST2, gD-type 3-O-sulfotransferase-2, gD-type-3-OST-2, glucosaminyl 3-O-sulfotransferase 3a,3b, heparan sulfate (glucosamine) 3-O-sulfotransferase 2, heparan sulfate 3-O-sulfotransferase, heparan sulfate 3-O-sulfotransferase 2, heparan sulfate D-glucosaminy 3-O-sulfotransferase, HS 3-O-sulfotransferase 2, HS 3-OST-2, HS3ST2, More
EC Number 2.8.2.29
CAS Registry Number
Comments This enzyme sulfates the residues marked with an asterisk in sequences containing at least ¡úIdoA2S¡úGlcN*¡ú or ¡úGlcA2S¡úGlcN*¡ú (symbols as in?2-Carb-38). Preference for GlcN2S vs. unmodified GlcN has not yet been established. Additional structural features are presumably required for substrate recognition, since the 3-O-sulfated residue is of low abundance, whereas the above IdoA-containing sequence is quite abundant. This enzyme differs from the other [heparan sulfate]-glucosamine 3-sulfotransferases by modifying selected glucosamine residues preceded by GlcA2S; EC?2.8.2.23?([heparan sulfate]-glucosamine 3-sulfotransferase 1) prefers GlcA or IdoA, whereas EC?2.8.2.30?([heparan sulfate]-glucosamine 3-sulfotransferase 3) prefers IdoA2S.
Cofactor
History
Reactions 3′-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3′,5′-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate.

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