Converts hepoxilin A3?into trioxilin A3. Highly specific for the substrate, having only slight activity with other epoxides such as leukotriene A4?and styrene oxide [2]. Hepoxilin A3?is an hydroxy-epoxide derivative of arachidonic acid that is formed via the 12-lipoxygenase pathway [2]. It is probable that this enzyme plays a modulatory role in inflammation, vascular physiology, systemic glucose metabolism and neurological function [4]. In vertebrates, five epoxide-hydrolase enzymes have been identified to date: EC?3.3.2.6?(leukotriene-A4?hydrolase), EC?3.3.2.7?(hepoxilin-epoxide hydrolase), EC?3.3.2.9?(microsomal epoxide hydrolase), EC?3.3.2.10?(soluble epoxide hydrolase) and EC?3.3.2.11?(cholesterol 5,6-oxide hydrolase) [3].
