| Product Name |
hepsin |
| Example Structure |
 |
| Synonyms |
hepsin, S01.224, TMPRSS1, transmembrane serine protease 1, type II transmembrane serine protease |
| EC Number |
3.4.21.106 |
| CAS Registry Number |
|
| Comments |
This type-II membrane-associated serine peptidase has been implicated in cell growth and development [1,3]. The enzyme has been shown to activate blood coagulation factor VII by cleavage of the Arg152©àIle153?peptide bound in BHK cells, thus indicating a possible role in the initiation of blood coagulation [2]. There is no cleavage after aromatic or aliphatic residues [1]. The occupancy of the S2 site is an absolute requirement for catalysis and a basic residue at that site is preferred to an aliphatic residue. The nature of the residue at S3 also affects hydrolysis, with Gln being much more favourable than Ala [1]. Belongs in peptidase family?S1A. |
| Cofactor |
|
| History |
|
| Reactions |
Cleavage after basic amino-acid residues, with Arg strongly preferred to Lys. |
