| Product Name |
hercynylcysteine S-oxide lyase |
| Example Structure |
 |
| Synonyms |
Egt-2, Egt2, egt2+, egtE, ergothioneine biosynthesis protein 2, hercynylcysteine sulfoxide lyase, NCU01256 protein, NCU11365, PLP-dependent C-S lyase, SPBC660.12c |
| EC Number |
4.4.1.36 |
| CAS Registry Number |
|
| Comments |
Contains pyridoxal 5′-phosphate. The enzyme, characterized from the bacterium Mycobacterium smegmatis, cayalyses the last step in the pathway of ergothioneine biosynthesis. The enzyme forms a 2-sulfenohercynine intermediate, which is reduced to ergothioneine non-enzymically by a thiol. In vitro, DTT can serve this function.
The enzyme, characterized from the bacterium Mycobacterium smegmatis, cayalyses the last step in the pathway of ergothioneine biosynthesis. The enzyme forms a 2-sulfenohercynine intermediate, which is reduced to ergothioneine non-enzymically by a thiol. In vitro, DTT can serve this function. |
| Cofactor |
pyridoxal 5′-phosphate |
| History |
|
| Reactions |
S-(hercyn-2-yl)-L-cysteine S-oxide + reduced acceptor = ergothioneine + pyruvate + ammonia + acceptor. |
