histone deacetylase EC#: 3.5.1.98; ChemWhat Code: 1381304
| Product Name | histone deacetylase |
| Example Structure |  |
| Synonyms | AtHD1, class I HDAC, class I histone deacetylase, class II histone deacetylase, class IIa histone deacetylase, Clr6, cytoplasmic deacetylase, deacetylase-like amidohydrolase, dRPD3, FB188 HDAH, HD1B, HD2, HD8, HDA, HDA-1, HDA-2, HDA-3, HDA-4, HdaA, HDAC, HDAC 11, HDAC 3, HDAC1, HDAC10, HDAC2, HDAC2-1, HDAC2-2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC6p114, HDAC6p131, HDAC7, HDAC8, HDAH, HDLP, histone deacetylase, histone deacetylase 1, histone deacetylase 10, histone deacetylase 11, histone deacetylase 2, histone deacetylase 3, histone deacetylase 4, histone deacetylase 6, histone deacetylase 7, histone deacetylase 8, histone deacetylase-1, histone deacetylase-7, histone deacetylase-like protein, histone deacetylase1, Hos2, HosB, pfHDAC-1, RPD3, Set3 complex, Set3C, tubulin deacetylase, zinc-dependent histone deacetylase, Zn(II)-dependent deacetylase, Zn-HDAC |
| EC Number | 3.5.1.98 |
| CAS Registry Number | |
| Comments | A class of enzymes that remove acetyl groups from?N6-acetyl-lysine residues on a histone. The reaction of this enzyme is opposite to that of EC?2.3.1.48, histone acetyltransferase. Histone deacetylases (HDACs) can be organized into three classes, HDAC1, HDAC2 and HDAC3, depending on sequence similarity and domain organization. Histone acetylation plays an important role in regulation of gene expression. In eukaryotes, HDACs play a key role in the regulation of transcription and cell proliferation [4]. May be identical to EC?3.5.1.17, acyl-lysine deacylase. |
| Cofactor | |
| History | |
| Reactions | Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone. |
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