[histone H3]-dimethyl-L-lysine36 demethylase EC#: 1.14.11.27; ChemWhat Code: 1375108

Product Name [histone H3]-dimethyl-L-lysine36 demethylase
Example Structure Example Structure of [histone H3]-dimethyl-L-lysine36 demethylase EC#: 1.14.11.27
Synonyms AN1060, CG33182, CG33185, dJMJD2(1), dJMJD2(1)/CG15835, dJMJD2(2), dJMJD2(2)/CG33182, dKDM2, dKDM4A, dRAF, GASC1, Gis1, H3-K36 demethylase, H3-K36-specific demethylase, H3K36 demethylase, H3K36 histone demethylase, H3K36me2 demethylase, H3K36me2 histone demethylase, H3K36me2-specific demethylase, H3K9/36me3 lysine demethylase, H3K9/H3K36 histone demethylase, histone demethylase, histone demethylase JmjD2A, histone H3 demethylase, histone H3 lysine 36 demethylase, histone H3 lysine 36 dimethyl¨Cspecific demethylase, histone H3K36 demethylase, histone H3K9/H3K36 trimethyldemethylase, histone-lysine(H3-K36) demethylase, histoneH3 demethylase, Jhd1, JHDM1A, Jhdm1b/Kdm2b, JmjC demethylase, JmjC domain histone demethylase, JmjC domain lysine demethylase, JmjC domain-containing histone demethylase 1, JmjC domain-containing histone demethylase 1A, JmjC domain-containing histone demethylation protein 3A, JmjC domain-containing histone demethylation protein 3b, JmjC histone lysine demethylase, JmjC protein, JmjC+N, JmjC+N histone demethylase, JMJD2, Jmjd2 demethylase, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD5, JumonjiC demethylase, KDM2B, KDM2b/JHDM1b, KDM4, KDM4A, KDM4A demethylase, KDM4A/JMJD2A, KDM4B, Kdm4c, KDM4D, KDM8, KdmA, lysine demethylase, More, Ndy1, PfJmjC1, Rph1, Rph1/KDM4, scJHDM1, [histone-H3]-lysine-36 demethylase 1
EC Number 1.14.11.27
CAS Registry Number
Comments Requires iron(II). Of the seven potential methylation sites in histones H3 (K4, K9, K27, K36, K79) and H4 (K20, R3) from HeLa cells, the enzyme is specific for Lys36. Lysine residues exist in three methylation states (mono-, di- and trimethylated). The enzyme preferentially demethylates the dimethyl form of Lys36 (K36me2), which is its natural substrate, to form the monomethylated and unmethylated forms of Lys36. It can also demethylate monomethylated (but not the trimethylated) Lys36. cf. EC 1.14.11.69, [histone H3]-trimethyl-L-lysine36 demethylase.
Cofactor Fe2+
History
Reactions Protein N(6),N(6)-dimethyl-L-lysine + 2 2-oxoglutarate + 2 O(2) = protein L-lysine + 2 succinate + 2 formaldehyde + 2 CO(2).

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