[histone H3]-dimethyl-L-lysine9 demethylase EC#: 1.14.11.65; ChemWhat Code: 1375161
| Product Name | [histone H3]-dimethyl-L-lysine9 demethylase |
| Example Structure | ![Example Structure of [histone H3]-dimethyl-L-lysine9 demethylase EC#: 1.14.11.65](/wp-content/uploads/enzyme-structure/1.14.11.65.jpg) |
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| EC Number | 1.14.11.65 |
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| Comments | Requires iron(II). This entry describes a group of enzymes that demethylate N-methylated Lys-9 residues in the tail of the histone protein H3 (H3K9). This lysine residue can exist in three methylation states (mono-, di- and trimethylated), but this group of enzymes only act on the the di- and mono-methylated forms. The enzymes are dioxygenases and act by hydroxylating the methyl group, forming an unstable hemiaminal that leaves as formaldehyde. cf. EC 1.14.11.66, [histone H3]-trimethyl-L-lysine9 demethylase. |
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