[histone H3]-lysine27 N-trimethyltransferase EC#: 2.1.1.356; ChemWhat Code: 1376642

Product Name [histone H3]-lysine27 N-trimethyltransferase
Example Structure Example Structure of [histone H3]-lysine27 N-trimethyltransferase EC#: 2.1.1.356
Synonyms CLF, EZH1, EZH2, histone H3 lysine 27 methyltransferase, histone lysine methyltransferase, HMTase, interleukin-5 response element II binding protein, KMT6A, KMT6B, Polycomb repressive complex 2, PRC2, RE-IIBP, SET domain histone lysine methyltransferase, vSET, WHSC1/MMSET isoform RE-IIBP
EC Number 2.1.1.356
CAS Registry Number
Comments This entry describes enzymes that successively methylate the L-lysine27 residue of histone H3 (H3K27), ultimately generating a trimethylated form. These modifications influence the binding of chromatin-associated proteins. The methylation of lysine27 leads to transcriptional repression of the affected target genes. The enzyme associates with other proteins to form a complex that is essential for activity. The enzyme can also methylate some non-histone proteins. Formerly EC 2.1.1.43.
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