[histone H3]-trimethyl-L-lysine27 demethylase EC#: 1.14.11.68; ChemWhat Code: 1375164

Product Name [histone H3]-trimethyl-L-lysine27 demethylase
Example Structure Example Structure of [histone H3]-trimethyl-L-lysine27 demethylase EC#: 1.14.11.68
Synonyms JMJD3, KDM6A, KDM6C, UTX, UTY
EC Number 1.14.11.68
CAS Registry Number
Comments Requires iron(II). This entry describes a group of enzymes that demethylate N-methylated L-lysine residues at position 27 of histone H3 (H3K27). The enzymes are dioxygenases and act by hydroxylating the methyl group, forming an unstable hemiaminal that leaves as formaldehyde. They can act on tri- and di-methylated forms, but have no activity with the mono-methylated form.
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