[histone H3]-trimethyl-L-lysine36 demethylase EC#: 1.14.11.69; ChemWhat Code: 1375165

Product Name [histone H3]-trimethyl-L-lysine36 demethylase
Example Structure Example Structure of [histone H3]-trimethyl-L-lysine36 demethylase EC#: 1.14.11.69
Synonyms JHDM3A, JMJD2A, JMJD2B, KDM4A, KDM4B, Rph1
EC Number 1.14.11.69
CAS Registry Number
Comments Requires iron(II). This entry describes a group of enzymes that demethylate N-methylated Lys36 residues in the tail of the histone protein H3 (H3K36). This lysine residue can exist in three methylation states (mono-, di- and trimethylated), but this group of enzymes only act on the the tri- and di-methylated forms. The enzymes are dioxygenases and act by hydroxylating the methyl group, forming an unstable hemiaminal that leaves as formaldehyde. Since trimethylation of H3K36 enhances transcription, this enzyme acts as a transcription repressor. The enzymes that possess this activity often also catalyse the activity of EC 1.14.11.66, [histone H3]-trimethyl-L-lysine9 demethylase. cf. EC 1.14.11.27, [histone H3]-dimethyl-L-lysine36 demethylase.
Cofactor
History
Reactions

Buy Reagent

No reagent supplier? Send quick inquiry to ChemWhat
Want to be listed here as a reagent supplier? (Paid service) Click here to contact ChemWhat

Approved Manufacturers

Want to be listed as an approved manufacturer (Requires approvement)? Please download and fill out this form and send back to approved-manufacturers@chemwhat.com

Other Suppliers

Watson International Limited Visit Watson Official Website

Contact Us for Other Help

Contact us for other information or services Click here to contact ChemWhat