| Synonyms |
13-HSL, alpha/beta hydrolase, Blip, cardiac HSL, cold-active hormone-sensitive lipase, Est06, Est22, Est25, EstB, EstE5, EstE5 protein, family IV carboxylesterase, hormone-sensitive lipase, HSL, HSL protein, HSL-like carboxylesterase, HSL1, HSL2, HslB, Lip1, LIP2, LIP3, LipY, MdL2, MgLip2, MgLip3, MGL_0797, MGL_0799, MGL_4054, MGL_4197, MgMDL2, ovHSL, ovHSL-A, ovHSL-B, Rv3097c, secreted lipase, SSO2517, SsoNDELTA, SsoNDELTAlong, SsoP1Est |
| Comments |
This enzyme is a serine hydrolase. Compared with other lipases, hormone-sensitive lipase has a uniquely broad substrate specificity. It hydrolyses all acylglyerols (triacylglycerol, diacylglycerol and monoacylglycerol) [2,3,4] as well as cholesteryl esters [2,4], steroid fatty acid esters [5], retinyl esters [6] and?p-nitrophenyl esters [4,7]. It exhibits a preference for the 1- or 3-ester bond of its acylglycerol substrate compared with the 2-ester bond [8]. The enzyme shows little preference for the fatty acids in the triacylglycerol, although there is some increase in activity with decreasing chain length. The enzyme activity is increased in response to hormones that elevate intracellular levels of cAMP. |
