hyaluronate lyase EC#: 4.2.2.1; ChemWhat Code: 1382493
| Product Name | hyaluronate lyase |
| Example Structure |  |
| Synonyms | acidic hyase, bacterial HAse, bacterial hyaluronidase, bacterial spreading factor, bacteriophage-associated hyaluronate lyase, Cumulase, EC 4.2.99.1, GBS HA lyase, GBS hyase, glucuronoglycosaminoglycan lyase, h-SD, h-SH, HA lyase, HL, Hyal, Hyal-1, Hyal-2, HYAL1, Hyal2, HYAL3, hyaluronan lyase, hyaluronate lyase, hyaluronate lyase HylA, hyaluronate lyase HylP2, hyaluronidase, hyaluronidase 3, hyaluronidase SD, hyaluronidase SH, hyaluronidase-1, hyaluronidase-2, hyaluronoglucosaminidase-1, hyaluronoglucosaminidase-2, HYase, HylA7, hylB, hylB4755, HylP, Hylp2, LUCA-1, LUCA-2, lyase, glucuronoglycosaminoglycan, lyase, hyaluronate, More, mucinase, protein SEQ2045, Q59801 {SwissProt}, rHuPH20, SagHL, SagHyal, spnHL, SpnHyal, spreading factor, SP_0314 |
| EC Number | 4.2.2.1 |
| CAS Registry Number | 37259-53-3 |
| Comments | The enzyme catalyses the degradation of hyaluronan by a ¦Â-elimination reaction. Also acts on chondroitin. Formerly EC?4.2.99.1. The product is more systematically known as 3-(4-deoxy-¦Á-L-threo-hex-4-enopyranosyluronic acid)-2-acetamido-2-deoxy-D-glucose. |
| Cofactor | |
| History | |
| Reactions | Cleaves hyaluronate chains at a beta-D-GlcNAc-(1->4)-beta-D-GlcA bond, ultimately breaking the polysaccharide down to 3-(4-deoxy-beta-D-gluc-4- enuronosyl)-N-acetyl-D-glucosamine. |
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