hydantoin racemase EC#: 5.1.99.5; ChemWhat Code: 1383158
| Product Name | hydantoin racemase |
| Example Structure |  |
| Synonyms | 5′-monosubstituted-hydantoin racemase, hydantoin racemase, HyuA, HyuE |
| EC Number | 5.1.99.5 |
| CAS Registry Number | |
| Comments | This enzyme, along with?N-carbamoylase (EC?3.5.1.77?and EC?3.5.1.87) and hydantoinase, forms part of the reaction cascade known as the “hydantoinase process”, which allows the total conversion of?D,L-5-monosubstituted hydantoins into optically pure?D- or?L-amino acids [7]. The enzyme from?Pseudomonas?sp. (HyuE) has a preference for hydantoins with aliphatic substituents, e.g.?D- and?L-5-[2-(methylsulfanyl)ethyl]hydantoin, whereas that from?Arthrobacter aurescens?shows highest activity with arylalkyl substituents, especially 5-benzylhydantoin, at the 5-position [2]. In the enzyme from?Sinorhizobium meliloti, Cys76?is responsible for recognition and proton retrieval of?D-isomers, while Cys181?is responsible for?L-isomer recognition and racemization [6]. |
| Cofactor | |
| History | |
| Reactions | D-5-monosubstituted hydantoin = L-5-monosubstituted hydantoin. |
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