hydroperoxy icosatetraenoate dehydratase EC#: 4.2.1.152; ChemWhat Code: 1382465

Product Name hydroperoxy icosatetraenoate dehydratase
Example Structure Example Structure of hydroperoxy icosatetraenoate dehydratase EC#: 4.2.1.152
Synonyms ALOXE3, eLOX-3, eLOX3, epidermal lipoxygenase-3, epidermal LOX type 3, epidermis-type lipoxygenase 3, hepoxilin synthase
EC Number 4.2.1.152
CAS Registry Number
Comments Binds Fe2+. The mammalian enzymes accept a range of hydroperoxy icosatetraenoates (HPETE). The human enzyme has highest activity with (12R)-HPETE, followed by (12S)-HPETE and (15R)-HPETE with much lower efficiency. The murine enzyme has highest activity with (8R)-HPETE followed by (8S)-HPETE. All HPETE isoforms are converted to the corresponding oxoicosatetraenoate forms (KETE) [2]. The enzymes also catalyse the reaction of EC?5.4.4.7, hydroperoxy icosatetraenoate isomerase.
Cofactor Fe2+
History
Reactions A hydroperoxy icosatetraenoate = an oxoicosatetraenoate + H(2)O.

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