Binds Fe2+. The mammalian enzymes accept a range of hydroperoxy icosatetraenoates (HPETE). The human enzyme has highest activity with (12R)-HPETE, followed by (12S)-HPETE and (15R)-HPETE with much lower efficiency. The murine enzyme has highest activity with (8R)-HPETE followed by (8S)-HPETE. All HPETE isoforms are converted to the corresponding oxoicosatetraenoate forms (KETE) [2]. The enzymes also catalyse the reaction of EC?5.4.4.7, hydroperoxy icosatetraenoate isomerase.
Cofactor
Fe2+
History
Reactions
A hydroperoxy icosatetraenoate = an oxoicosatetraenoate + H(2)O.