[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase EC#: 2.7.11.31; ChemWhat Code: 1379035

Product Name [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase
Example Structure Example Structure of [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase EC#: 2.7.11.31
Synonyms 3-hydroxy-3-methylglutaryl coenzyme A reductase kinase, 3-hydroxy-3-methylglutaryl-CoA reductase kinase, 5′-AMP-activated protein kinase, 5′-AMP-activated protein kinase catalytic subunit alpha-1, 5-AMP-activated protein kinase, AAK-2, adenosine 5′-monophosphate-activated protein kinase, adenosine 5-monophosphate-activated protein kinase, adenosine monophosphate-activated protein kinase, adenosine monophosphateactivated protein kinase, AMP-activated protein kinase, AMP-activated protein kinase alpha, AMP-activated protein kinase alpha1, AMP-activated protein kinase alpha2 subunit, AMPK, AMPK-223, AMPK1, AMPKalpha, AMPKbeta, AMPKbeta-1, AMPKbeta-2, AMPKgamma, beta-hydroxy-beta-methylglutaryl-CoA reductase kinase, HDAC5 kinase, hydroxymethylglutaryl coenzyme A reductase kinase, hydroxymethylglutaryl coenzyme A reductase kinase (phosphorylating), More, PRKAA1, reductase kinase, Snf1, Snf1 kinase, SNF1-interacting protein 1, SNF1-interacting protein 2, SNF1-interacting protein 3, SNF4, [hydroxymethylglutaryl-CoA reductase (NADPH2)] kinase
EC Number 2.7.11.31
CAS Registry Number 172522-01-9
Comments The enzyme is activated by AMP. EC?1.1.1.34, hydroxymethylglutaryl-CoA reductase (NADPH), is inactivated by the phosphorylation of the enzyme protein. Histones can also act as acceptors. The enzyme can also phosphorylate hepatic acetyl-CoA carboxylase (EC?6.4.1.2) and adipose hormone-sensitive lipase (EC?3.1.1.79) [5]. Thr-172 within the catalytic subunit (¦Á-subunit) is the major site phosphorylated by the AMP-activated protein kinase kinase [7]. GTP can act instead of ATP [4].
Cofactor
History
Reactions Atp + [hydroxymethylglutaryl-CoA reductase (NADPH)] = adp + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate.

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