hypoxia-inducible factor-asparagine dioxygenase EC#: 1.14.11.30; ChemWhat Code: 1375114
| Product Name | hypoxia-inducible factor-asparagine dioxygenase |
| Example Structure |  |
| Synonyms | asparaginyl hydroxylase, asparaginyl-hydroxylase, factor inhibiting HIF, factor inhibiting HIF-1, factor inhibiting hypoxia inducible factor-1alpha, factor-inhibiting HIF, factor-inhibiting hypoxia-inducible factor, FIH, FIH hydroxylase, HIF asparagine hydroxylase, HIF asparaginyl hydroxylase, HIF hydroxylase, hypoxia-inducible factor asparagine hydroxylase |
| EC Number | 1.14.11.30 |
| CAS Registry Number | |
| Comments | Contains iron, and requires ascorbate. Catalyses hydroxylation of an asparagine in the C-terminal transcriptional activation domain of HIF-¦Á, the ¦Á subunit of the transcriptional regulator HIF (hypoxia-inducible factor), which reduces its interaction with the transcriptional coactivator protein p300. The requirement of oxygen for the hydroxylation reaction enables animals to respond to hypoxia. |
| Cofactor | Fe2+;L-ascorbate |
| History | |
| Reactions | Hypoxia-inducible factor-L-asparagine + 2-oxoglutarate + O(2) = hypoxia- inducible factor-(3S)-3-hydroxy-L-asparagine + succinate + CO(2). |
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