| Synonyms |
CHUK, I kappa B kinase alpha, I-kappa B kinase epsilon, Ikappa B kinase alpha, IkappaB alpha kinase, IkappaB kinase, IkappaB kinase alpha, IkappaB kinase beta, IkappaB kinase complex, IkappaB kinase epsilon, IkappaB kinase-1, IkappaB kinase-2, IkappaB kinase-alpha, IkappaB kinase-beta, IkappaB-kinase, IkappaBalpha, IkappaBalpha kinase, IkappaBbeta kinase, IKK, IKK beta, IKK complex, IKK-1, IKK-2, IKK-alpha, IKK-beta, IKK-related kinase, IKK1, IKK2, Ikka, IKKalpha, IKKbeta, IKKepsilon, IKKi, inhibitor of kappaB kinase, inhibitor of nuclear factor kappa B kinase beta subunit, inhibitor of nuclear factor kappa B kinase beta subunit inhibitor of nuclear factor kappa-B kinase alpha subunit, inhibitor of nuclear factor kappa-B kinase alpha subunit, inhibitor of nuclear factor kappa-B kinase epsilon subunit, inhibitor of nuclear factor kB kinase-related kinase, LRRK2 kinase, non-canonical IkappaBkinase epsilon, serine/threonine-protein kinase pkn1, TANK-binding kinase 1, TBK1, TBK1 kinase |
| Comments |
The enzyme phosphorylates I¦ÊB proteins at specific serine residues, which marks them for destruction via the ubiquitination pathway. Subsequent degradation of the I¦ÊB complex (IKK) activates NF-¦ÊB, a translation factor that plays an important role in inflammation, immunity, cell proliferation and apoptosis. If the serine residues are replaced by threonine residues, the activity of the enzyme is decreased considerably. |
