Imatinib mesylate CAS#: 220127-57-1; ChemWhat Code: 41692

IdentificationPhysical DataSpectra
Route of Synthesis (ROS)Safety and HazardsOther Data

Identification

Product NameImatinib mesylate
IUPAC Namemethanesulfonic acid;4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide
Molecular StructureImatinib-mesylate-CAS-220127-57-1
CAS Registry Number 220127-57-1
Synonyms4-[(4-Methyl-1-piperazinyl)methyl]-N-(4-methyl-3-{[4-(3-pyridinyl)-2-pyrimidinyl]amino}phenyl)benzamide methanesulfonate;4-[(4-Methyl-1-piperazinyl)methyl]-N-(4-methyl-3-{[4-(3-pyridinyl)-2-pyrimidinyl]amino}phenyl)benzamide methanesulfonate (1:1) [ACD/IUPAC Name];4-[(4-Methylpiperazin-1-yl)methyl]-N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)benzamide methanesulfonate;4-[(4-Methylpiperazin-1-yl)methyl]-N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)benzam
de methanesulfonate (1:1);Acide méthanesulfonique – 4-[(4-méthyl-1-pipérazinyl)méthyl]-N-(4-méthyl-3-{[4-(3-pyridinyl)-2-pyrimidinyl]amino}phényl)benzamide (1:1)[French] [ACD/IUPAC Name];acide méthanesulfonique – 4-[(4-méthylpipérazin-1-yl)méthyl]-N-{4-méthyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phényl}benzamide (1:1) [French];Benzamide, 4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-, methanesulfonate (1:1) [ACD/Index Name];Glivec [Trade name];Imatinib mesilate [JAN];Imatinib mesilate (JAN);Imatinib mesylate;Methansulfonsäure –4-[(4-methyl-1-piperazinyl)methyl]-N-(4-methyl-3-{[4-(3-pyridinyl)-2-pyrimidinyl]amino}phenyl)benzamid (1:1) [German] [ACD/IUPAC Name];Methansulfonsäure–4-[(4-methylpiperazin-1-yl)methyl]-N-{4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl}benzolcarboxamid(1:1);[220127-57-1];{4-[(4-methylpiperazinyl)methyl]phenyl}-N-{4-methyl-3-[(4-(3-pyridyl)pyrimidin-2-yl)amino]phenyl}carboxamide, methanesulfonic acid;10229624 [Beilstein];14337-43-0 [RN];152459-95-5 [RN];220127-57-1 [RN];4-((4-Methylpiperazin-1-yl)methyl)-N-(4-methyl-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)phenyl)benzamide Monomethanesulfonate;4-(4-Methyl-piperazin-1-ylmethyl)-N-[4-methyl-3- (4-pyridin-3-yl)-pyrimidin-2-ylamino)-phenyl]-benzamidemethanesulf onic acid salt;4-(4-Methyl-piperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin- 3-yl)-pyrimidin-2-ylamino)-phenyl]-benzamidemethanesulfonic acid salt;4-(4-Methyl-piperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide;4-(4-Methylpiperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)phenyl]benzamide methanesulfonic acid salt;4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-benzamide monomethanesulfonate;4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridyl)-2-pyrimidinyl]amino]phenyl]benzamide;4-[(4-Methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide;4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[[4-(3-pyridyl)pyrimidin-2-yl]amino]phenyl]benzamide;4-[(4-methylpiperazin-1-yl)methyl]-N-{4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl}benzamidemethanesulfonate;Benzamide, 4-((4-methyl-1-piperazinyl)methyl)-N-(4-methyl-3-((4-(3-pyridinyl)-2-pyrimidinyl)amino)phenyl)-, monomethanesulfonate;Benzamide, 4-[ (4-methyl-1-piperazinyl)methyl]-N-[[4- methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-, monomethanesulfonate;Benzamide, 4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl- 3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-,monomethanesulfonate;CGP 57148B;CGP-57148B;GGP-57148B;Gleevac;Gleevec (TN);Gleevec; Glivec;Glivec (TN);Glivec, CGP-57148B, STI-571;Imatinib (mesylate);Imatinib mesylate ¼×»ÇËáÒÁÂêÌæÄá;Imatinib Mesylate (STI571);Imatinib methane sulfonate;IMATINIB METHANESULFONATE;imatinib methansulfonate;imatinib monomesylate;IMATINIB MESYLATE;Imatinib, methanesulfonate salt;Methanesulfonic acid [ACD/Index Name] [ACD/IUPAC Name] [Wiki];methanesulfonic acid;4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide;MFCD04307699 [MDL number];N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide methanesulfonate;N-(4-methyl-3(4-(pyridin-3-yl)pyridin-2-ylamino)phenyl-4-((4-methylpiperazin-1-yl)methyl)benzamide;N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)-4-[(4-methylpiperazin-1-yl)methyl]benzamide;NSC-716051;Pirarubicin [INN] [JP15] [Wiki];TL8006192;UNII-8A1O1M485B;α-IMATINIB MESYLATE
Molecular FormulaC30H35N7O4S
Molecular Weight589.7
InChIInChI=1S/C29H31N7O.CH4O3S/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36;1-5(2,3)4/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34);1H3,(H,2,3,4)
InChI KeyYLMAHDNUQAMNNX-UHFFFAOYSA-N
Canonical SMILESCC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC=CC(=N4)C5=CN=CC=C5.CS(=O)(=O)O
Patent Information
No data available

Physical Data

AppearanceWhite to light yellow crystal power
Melting Point214-224°C
SolubilityH2O: soluble10mg/mL, clear

Spectra

Description (NMR Spectroscopy)Nucleus (NMR Spectroscopy)
Chemical shifts1H
Chemical shifts 13C
Imatinib mesylate CAS#: 220127-57-1 LC-MSLC-MS of Imatinib mesylate CAS 220127-57-1

Route of Synthesis (ROS)

No data available

Safety and Hazards

Pictogram(s)exclamation-markhealth-hazard
SignalDanger
GHS Hazard StatementsH302: Harmful if swallowed [Warning Acute toxicity, oral]
H351: Suspected of causing cancer [Warning Carcinogenicity]
H360: May damage fertility or the unborn child [Danger Reproductive toxicity]
Information may vary between notifications depending on impurities, additives, and other factors.
Precautionary Statement CodesP201, P202, P264, P270, P281, P301+P312, P308+P313, P330, P405, and P501
(The corresponding statement to each P-code can be found at the GHS Classification page.)
For more detailed information, please visit ECHA C&L website

Other Data

TransportationNot dangerous goods
Under the room temperature and away from light
HS Code294200
StorageUnder the room temperature and away from light
Shelf Life2 years
Market PriceUSD 510/kg
Use Pattern
Imatinib mesylate is a tyrosine kinase inhibitor with antineoplastic activity. Imatinib is a potent inhibitor of the Bcr-Abl kinase encoded by the bcr-abl oncogene as well as receptor tyrosine kinases encoded by c-kit and platelet-derived growth factor receptor (PDGFR) oncogenes. Imatinib mesylate inhibition of Bcr-Abl tyrosine kinase created by the Philadelphia chromosome abnormality found in CML decreases proliferation and enhances apoptosis in leukemias CML and ALL. Inhibition of c-kit tyrosine activity inhibits mast-cell and cellular proliferation in those diseases overexpressing c-kit such as gastrointestinal stromal tumor (GIST).
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.

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Caming Pharmaceutical Ltdhttp://www.caming.com/
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