| Product Name |
indolepyruvate ferredoxin oxidoreductase |
| Example Structure |
 |
| Synonyms |
3-(indol-3-yl)pyruvate synthase (ferredoxin), arylpyruvate-ferredoxin oxidoreductase, hydroxyphenylpyruvate oxidase, indolepyruvate oxidase, indolepyruvate-ferredoxin oxidoreductase, indolepyruvate:Fd oxidoreductase, IOR, phenylpyruvate oxidase, VOR |
| EC Number |
1.2.7.8 |
| CAS Registry Number |
|
| Comments |
Contains thiamine diphosphate and [4Fe-4S] clusters. Preferentially utilizes the transaminated forms of aromatic amino acids and can use phenylpyruvate and 4-hydroxyphenylpyruvate as substrates. This enzyme, which is found in archaea, is a member of the 2-oxoacid oxidoreductases, a family of enzymes that oxidatively decarboxylate different 2-oxoacids to form their CoA derivatives, and are differentiated based on their substrate specificity. For examples of other members of this family, see EC 1.2.7.3, 2-oxoglutarate synthase and EC 1.2.7.7, 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin). |
| Cofactor |
iron-sulfur;thiamine diphosphate |
| History |
|
| Reactions |
(Indol-3-yl)pyruvate + CoA + 2 oxidized ferredoxin = S-2-(indol-3- yl)acetyl-CoA + CO(2) + 2 reduced ferredoxin + H(+). |
