| Synonyms |
1,3,4-trisphosphate 5/6-kinase, 5/6 kinase, 5/6-kinase, At2G43980, AtITPK1, AtITPK2, AtITPK3, AtITPK4, inositol 1,3,4-triphosphate 5/6 kinase, inositol 1,3,4-triphosphate 5/6-kinase, inositol 1,3,4-trisphosphate 5/6-kinase, inositol 1,3,4-trisphosphate 5/6-kinase 4, inositol-1,3,4-trisphosphate kinase, Ins(1,3,4)P3 5/6-kinase, IP56K, Itpk-1, ITPK1, ITPK2, ITPK3, More, OsITL1 |
| Comments |
In humans, this enzyme, along with EC?2.7.1.127?(inositol-trisphosphate 3-kinase), EC?2.7.1.140?(inositol-tetrakisphosphate 5-kinase) and EC?2.7.1.158?(inositol pentakisphosphate 2-kinase) is involved in the production of inositol hexakisphosphate (InsP6). InsP6?is involved in many cellular processes, including mRNA export from the nucleus [2]. Yeast do not have this enzyme, so produce InsP6?from Ins(1,4,5)P3?by the actions of EC?2.7.1.151?(inositol-polyphosphate multikinase) and EC?2.7.1.158?(inositol-pentakisphosphate 2-kinase) [2]. |
| Reactions |
(1) Atp + 1D-myo-inositol 1,3,4-trisphosphate = adp + 1D-myo-inositol 1,3,4,5-tetrakisphosphate. (2) Atp + 1D-myo-inositol 1,3,4-trisphosphate = adp + 1D-myo-inositol 1,3,4,6-tetrakisphosphate. |
